MisoOne® - Medical Termination Of Pregnancy Solution

MisoOne - Unveiling the Intricacies of 400 Microgram:  Misoprostol and Beyond

For important information about this medicine, before use. If you have any questions, consult your doctor. Remember, this medicine is prescribed specifically for you; Do not share it with others, as it may adversely affect them. There may be effects, even if the symptoms are similar. If you experience any side effects, contact your healthcare provider, including effects not listed (see section 4). Your well-being is our priority.

What is MisoOne? 

MisoOne belongs to the class of drugs known as abortifacients, which are prescribed to aid in medically terminating pregnancies prior to 60 days after menses begin. In some cases, MisoOne may even be used during the 2nd trimester of pregnancy.

It is a combination of two medicines, mifepristone and misoprostol. Mifepristone acts as an anti-hormone (anti-progestogen), which reduces the effects of progesterone hormone on pregnant women.

On the other hand, Misoprostol acts as a prostaglandin that enhances your womb's contracture and dilates your cervix - effectively ending your pregnancy. Thus, using both drugs together in combination will result in medical abortion; these should be administered sequentially for best results. 

What MisoOne is and what it is used for 

MisoOne tablets contain misoprostol, a compound akin to the natural 'prostaglandin' your body produces. Misoprostol induces uterine contractions and cervical softening.
For medical pregnancy termination, MissiOn complements mifepristone. It should be ingested within 60 days of your last menstrual period.
In surgical pregnancy termination during the first trimester (within 9 weeks of your menstrual cycle), MisoOne is used as a standalone medication.
MisoOne serves these crucial roles in reproductive healthcare, aiding both medical and surgical pregnancy termination processes.

What you need to know before you take MisoOne

Do not use MisoOne if

  1. You are allergic to misoprostol, any other prostaglandins, or any of the listed ingredients
  2. Pregnancy has not been confirmed through ultrasound scan or biological testing.
  3. Your doctor suspects an ectopic pregnancy (in which the egg implants outside the uterus).
  4. You cannot take mifepristone when it is used in combination with MisoOne.
  5. For medical pregnancy termination, if it has been more than 60 days (9 weeks) since the first day of your last menstrual period

Warnings and Precautions:

  1. Have liver or kidney disease.
  2. Experience anemia or malnutrition.
  3. Have a history of cardiovascular disease, encompassing heart or circulatory issues. 
  4. Are at an elevated risk of cardiovascular disease, particularly if you're over 35 years old, a smoker, or have high blood pressure, elevated blood cholesterol levels, or diabetes.
    Suffer from a condition affecting blood clotting.
  5. Have a history of previous cesarean section or uterine surgery.
  • Healthcare professionals must ensure patients are well-informed about the potential risks, such as the possibility of method failure and birth defects, including the risk of teratogenicity in ongoing pregnancies.
  • It is essential to schedule a follow-up visit to verify the completion of the expulsion, as detailed in the Pregnancy, Breast-Feeding, and Fertility section.
  • Before initiating mifepristone and MisoOne, a blood test will be conducted to determine your Rhesus factor. If you are Rhesus negative, your doctor will provide guidance on the necessary routine treatment.

For surgical termination of pregnancy

  • As there is a lack of data on cervical preparation using misoprostol beyond the first trimester, MisoOne should not be administered beyond 12 weeks from the onset of your menstrual cycle.
  • Furthermore, considering the potential for vaginal bleeding after taking this medication, it is advisable to take MisoOne at the treatment center before the surgical procedure. This precaution ensures a safer and more controlled environment for the process

Inform your doctor about any other medications you are currently taking, have recently taken, or plan to take, including those obtained without a prescription.

  • Non-steroidal anti-inflammatory drugs (NSAIDs) like acetylsalicylic acid or diclofenac.
  • Antacid medications or any antacid containing magnesium, typically used for heartburn and acid indigestion.

 Pregnancy, breast-feeding and fertility

Notably, the failure of pregnancy termination (leading to a continuing pregnancy) subsequent to MisoOne usage has been linked to a threefold elevated risk of birth defects, including facial paralysis, head, and limb malformations. Similar defects have been observed when this medication is used independently.

For medical pregnancy termination, it is imperative to use another medication, mifepristone, 36 to 48 hours before taking MisoOne.

The risk of MisoOne failure heightens under the following circumstances

  • If it's not taken orally.
  • With prolonged pregnancy duration.
  • With an increasing number of prior pregnancies.
  • In the case of medical pregnancy termination, if it's administered later than 49 days following the first day of your last menstrual period.

    In the event that the pregnancy termination is unsuccessful after using this medication, there exists an unknown risk to the fetus. Should you opt to proceed with the pregnancy, it is imperative to engage in meticulous prenatal monitoring and frequent ultrasound examinations, with a specific focus on the limbs and head. These assessments should be conducted at a specialized clinic, and your doctor will provide further guidance.

Conversely, if you decide to continue with the termination of the pregnancy, a new procedure will be recommended by your doctor, who will present you with the available options.

Furthermore, it is advisable to refrain from attempting pregnancy again until after your next menstrual cycle following the use of this medication. Initiate contraception immediately once the doctor confirms the successful termination of the pregnancy. This precaution ensures a safe and well-planned approach to future pregnancies.

For individuals who are currently breast-feeding, it's essential to consult your doctor for guidance before using this medication. It's recommended not to continue breast-feeding, as this medicine is transferred into breast milk.

It's noteworthy that this medication does not influence fertility. You can conceive again once the termination is successfully completed. To ensure a controlled approach, it's advisable to initiate contraception immediately after the doctor confirms the termination of the pregnancy. This enables a proactive approach to family planning.

Driving and Operating Machinery

It's important to be aware that this medication may induce dizziness. Therefore, exercise caution when driving or operating machinery after taking MisoOne until you have a clear understanding of how it may affect you. Your safety and the safety of others should be a priority during this period.

How to Take MisoOne

Always adhere to your doctor's instructions precisely. If you have any doubts, consult your doctor or pharmacist.

Dosage in Adults

  • Take one tablet orally

Taking the Tablet

  • In all cases
  • Swallow the tablet whole with a glass of water.
  • In case you vomit within 30 minutes of taking the tablet, contact your doctor immediately. You will need to take another tablet.

    Contact Your Prescribing Center Immediately After the Termination Procedure (Medical or Surgical) if
  • You experience vaginal bleeding for more than 12 days and/or if it is very heavy (a.s., you require more than 2 sanitary pads per hour for 2 hours).
  • You have severe abdominal pain.
  • You develop a fever or experience chills.

    For Medical Termination of Pregnancy
    The schedule for taking MisoOne for a medical termination of pregnancy is as follows
  • You will be given the first drug, mifepristone, at the prescribing center, which must be taken orally.
  • After 36-48 hours, you will take MisoOne orally. Rest for at least 3 hours following this intake.
  • The embryo may be expelled within a few hours of taking MisoOne or over the next few days. Expect vaginal bleeding,
  • which will last for approximately 12 days after taking the first drug, mifepristone, with a gradual reduction in flow.

Return to the center within 14-21 days after taking the first medicine, mifepristone, for a check-up consultation to ensure the expulsion is complete.

Important Things to Remember When Taking this Medicine

  • This tablet must be taken orally.
  • For medical termination of pregnancy, MisoOne must be taken 36-48 hours after taking 600 mg of mifepristone.
  • Failure to follow these instructions may increase the risks associated with this medicine.

    For Surgical Termination of Pregnancy

The tablet should be taken 3 to 4 hours before the surgical termination procedure of pregnancy.
The schedule for taking MisoOne for a surgical termination of pregnancy is as follows:

Take MisoOne orally.
The surgical procedure will be performed 3 to 4 hours after this intake

How to Store MisoOne

  • Keep this medicine out of the sight and reach of children.
  • Do not use this medicine after the expiry date, indicated on the carton as "EXP." The expiry date pertains to the last day of that month.
  • Store at temperatures below 25°C.
  • Do not utilize this medicine if you observe any signs of damage on the box or blister packs.
  • Do not use the tablet if it has been stored outside the blister pack.
  • When discarding unused medicines, do not dispose of them via wastewater. Consult your pharmacist for proper disposal instructions to help protect the environment.

    Contents of the Pack and Other Information
  • The active ingredient is misoprostol.
  • Each MisoOne tablet contains 400 micrograms of misoprostol.
  • Other ingredients include microcrystalline cellulose, hypromellose, sodium starch glycolate (type A), and hydrogenated castor oil.

What MisoOne Looks Like and Contents of the Pack

MisoOne is a white, round, flat tablet with a diameter of 11 mm and a thickness of 4.5 mm. It features a break line on each side and a double "M" engraved on one side, allowing the tablet to be divided into equal doses.

What is the Price of MisoOne?

Unwanted-Kit typically costs between $147 for a single box, though prices can vary based on location. Different countries have various laws regarding abortion which could influence pricing for certain products. 

What Are the Side Effects of MisoOne?

When used for abortion purposes, Misoprostol should produce abdominal cramps and bleeding. Pregnancy-related symptoms like nausea or vomiting may get worse after taking Mifepristone then decrease during Misoprostol administration; however these will subside during abortion procedure. It's also possible to experience adverse reactions like diarrhea, fevers and chills .

Typically, bleeding lasts 12-14 days and other symptoms appear for only 24 hours.

Side Effects of Unwanted Kit 

  • Nausea
  • Uterine cramps
  • Vomiting
  • Diarrhea
  • Dizziness
  • Infections after an abortion
  • Uterine bleeding
  • Infection (following an abortion)
  • Hypersensitivity reactions
  • Skin eruptions

Rare Side Effects of Unwanted Kit 

  • Headache
  • Malaise feeling unwell
  • Hot flushes
  • Dizziness
  • Chills Fever
  • Low blood pressure
  • Skin disorders
  • and hives Uterine rupture
  • and toxic shock